Autoimmune Blistering Dermatoses (AIBD)

AIBD are a group of rare skin disorders characterized by blistering and erosion, caused by the immune system mistakenly attacking healthy skin cells. Dr. Patel has extensive knowledge in managing and treating these conditions, gained through working under an international expert in AIBD during his residency training. This expertise enables him to excel in early diagnosis, effective treatment, and ongoing management of these complex conditions, with several patients in his local communities currently benefiting from his active care.


Types of AIBD

  1. Pemphigus: Autoantibodies target desmogleins, proteins that hold skin cells together, leading to blisters and erosion.

  2. Bullous Pemphigoid: Autoantibodies target proteins in the skin basement membrane, leading to blisters and itching.

  3. Epidermolysis Bullosa Acquisita: Autoantibodies target type VII collagen, leading to blisters and skin fragility.

  4. Dermatitis Herpetiformis: Autoantibodies target epidermal transglutaminase, leading to blisters and itching.


Causes

  • Genetic predisposition

  • Autoantibodies (mistakenly attacking healthy skin cells)

  • Medications (e.g., certain antibiotics, antihypertensives, and painkillers)

  • Environmental triggers (e.g., UV radiation, infections)

Treatments

  • Corticosteroids (topical or systemic) to reduce inflammation

  • Antibiotics: Doxycycline (to reduce inflammation and prevent infection)

  • Immunosuppressive medications to suppress autoantibody production

  • Intravenous immunoglobulin (IVIG) to neutralize autoantibodies

  • Rituximab (monoclonal antibody) to target B cells producing autoantibodies

  • Wound care and skin protection to prevent infections and promote healing


Additional Measures

  • Avoiding triggers (e.g., UV radiation, stress, discontinuation of offending medication)

  • Maintaining a healthy lifestyle (e.g., balanced diet, regular exercise)